LACHGAS FUNDAMENTALS EXPLAINED

The final proposed mechanism of RBC vasodilation from the existence of nitrite would be the reduction of nitrite to NO by Hb. Brooks initially analyzed the nitrite Hb interaction in 1937 and this do the job was later prolonged by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to kind metHb and NO (Brooks, 1937